Enhanced absorption of phenobarbital from suppositories containing phenobarbital-.BETA.-cyclodextrin inclusion complex.

Study of inclusion complex of beta-cyclodextrin and nitrobenzene.

beta-cyclodextrin can react with nitrobenzene to form an inclusion complex which is characterized by (1)H NMR and powder X-ray diffractometry. The ratio of beta-CD to NB in inclusion complex is determined as 1:1. At 25 degrees C, the dissociated constant, K(D), of the inclusion complex is measured as 6.5 x 10(-3) M in neutral solution (pH=7.0), but in alkali (pH=13.5), K(D) is 3.2 x 10(-2) M wh...

Effect of Formulation Variables on Phenobarbital Release from HPMC Matrices

        Controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (HPMC) as the matrix former. The effects of the viscosity grades of HPMC and HPMC/lactose ratio and ethylcellulose (EC)/sodium carboxymethylcellulose (NaCMC) and their concentrations on the release behavior of phenobarbital from HPMC matrices wer...

Conversion phenobarbital from po to iv

PO: Within 20-60 minutes. IV:PO conversion is 1:1.. Maintenance phenobarbital doses of 5 mg/kg/day may occasionally result in accumulation of serum . J Clin Pharmacol. 1978 Feb-Mar;18(2-3):100-5. Bioavailability of oral and intramuscular phenobarbital. Viswanathan CT, Booker HE, Welling PG. Jul 25, 2017. BRIVIACT can be initiated with either intravenous or oral administration. tablets to carbam...

Phenobarbital-induced Gingival Hyperplasia

Phenobarbital: missing in action.

Editorials 871 Epilepsy affects more than 60 million people worldwide, and over 80% of them live in resource-poor countries. 1 Approximately 85% of these people do not receive appropriate treatment 2 because of economic, cultural, social and legislative barriers, compounded by little interest on the part of pharmaceutical companies because drug distribution is not lucrative. Left untreated, peo...